Chemokines in the lung
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Chemokines in the lung

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Published by Marcel Dekker, Inc. in New York .
Written in English


  • Pneumonia -- Pathophysiology.,
  • Chemokines -- Pathophysiology.,
  • Lung Diseases -- immunology.,
  • Chemokines -- immunology.,
  • Chemotaxis, Leukocyte.,
  • Inflammation.,
  • Leukocytes -- immunology.

Book details:

Edition Notes

Statementedited by Robert M. Strieter, Steven L. Kunkel, Theodore J. Standiford.
SeriesLung biology in health and disease -- v. 172
ContributionsStrieter, Robert M., 1952-, Kunkel, S. L., Standiford, Theodore J.
LC ClassificationsRC771 .C484 2003
The Physical Object
Paginationxviii, 399 p. :
Number of Pages399
ID Numbers
Open LibraryOL22492043M
ISBN 10082470858X

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  This reference discusses the role of chemokines in mediating leukocyte trafficking, angiogenesis, tumor cell metastasis, host defense, trauma-induced lung injury, and the progression of AIDS in the lung, and studies cytokines as natural agents for modulating diseases that affect the by: Chemokines in the lung. Summary: Discusses the role of chemokines in mediating leukocyte trafficking, angiogenesis, tumour cell metastasis, host defence, trauma-induced lung injury, and the progression of AIDS in the lung. The text studies cytokines as natural agents for modulating diseases that affect the lung.   Book Review: Chemokines in the Lung. Robert M Strieter MD, Steven L Kunkel PhD, and Theodore J Standiford MD, editors. (Lung Biology in Health and Disease series, Volume , Claude Lenfant, executive editor).Author: Joan G Clark. INTRODUCTION; PREFACE; CONTRIBUTORS; CONTENTS; Introduction to Chemokines; Chemokine Receptors Signaling Mechanisms and Roles in Immunoregulation; Regulation of Chemokine Expression by STAT Proteins; The Role of Chemokines in Lymphocyte to Lymph Nodes of the Lung; Genetic Models to Study Chemokine Biology in the Lung; The Role of Chemokines in Asthmatic Airway Responses; Chemokines .

Summary Focusing on all the major cytokine families, this reference book provides coverage of cytokine regulatory processes in the lung and other tissues and comprehensive descriptions of cytokine functions specific to the lung.;Discussing the diverse cytokine-binding proteins and the role of cytokines in tissue injury and repair processes and extracellular matrix regulations, the book. Before birth, the lung is highly expanded with lung liquid and the degree of expansion is a major determinant of lung growth and maturation. After birth, the entry of air produces, for the first time, surface tension in the lung, which reduces lung expansion and alters the regulation of lung development. The finding that expression of chemokine receptors/chemokines is not only limited to inflammatory and immune cells, but also to the structural lung cells, attributes them a more significant role in the regulation of homeostasis in the lung. The chemokine receptors and their ligands, expressed by both inflammatory/immune and resident structural lung cells, act in a coordinated way and orchestrate the Cited by:   Idiopathic pulmonary fibrosis (IPF) exhibits a complex and poorly understood pathogenesis. Overt inflammation in the lungs of patients with established IPF is absent, and classic anti-inflammatory therapies are inefficacious; however, inflammation may contribute to the disruption of the normal alveolar architecture, allowing interaction between fibroblasts and the by:

This text, one of a continuing series in Lung Biology in Health and Disease, Cytokines of the Lung, has four parts: Mitogenic Cytokines, Pro-Inflammatory Cytokines, Cytokines in the Lung, and Cytokines With Special Effects. Within each part, there are several chapters for a total of 16, which include subjects such as platelet-derived growth factor, cell-like growth factors, transform Author: David S. Wilkes, Kathy Sietsema, John E. Mayer, John J. Tyner.   Polymorphonuclear cell (PMN) chemotaxis into the lung in acute lung injury (ALI). Chemokines are secreted at the site of inflammation by resident tissue cells, leukocytes, and cytokine-activated endothelial and epithelial by: The fact that chemokine receptors are differentially expressed on T‐cell subsets and that this differential expression results in selective migration of Th1 and Th2 cells to particular chemokines has led to the hypothesis that chemokines are responsible for the selective recruitment of antigen‐specific Th2 cells to the lung following Cited by:   Cytokines present in the lung clearly regulate both the initiation and maintenance of immune and inflammatory responses. Cytokines select the type of response generated and the effector mechanisms to be utilized. Cytokines are the intercellular words that provided instructions in Cited by: